Time Course of Serum Neuron-Specific Enolase

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Time course of serum neuron-specific enolase. A predictor of neurological outcome in patients resuscitated from cardiac arrest.

BACKGROUND AND PURPOSE The prediction of neurological outcome in comatose cardiac arrest survivors has enormous ethical and socioeconomic implications. The purpose of the present study was to investigate the prognostic relevance of the time course of serum neuron-specific enolase (NSE) as a biochemical marker of hypoxic brain damage. METHODS Serial analysis of serum NSE levels was performed i...

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Rapid electrophoretic determination of neuron-specific enolase isoenzymes in serum.

This assay procedure for each of the two neuron-specific enolases (alpha gamma and gamma gamma) and the non-neuronal enolase (alpha alpha) in serum involves two steps: electrophoretic separation of the three isoenzymes--alpha alpha, alpha gamma, and gamma gamma--on cellulose acetate, and bioluminescence measurement of total enolase activity. From these data, the activity concentrations (U/L) of...

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Neuron-specific enolase concentrations in serum in benign liver diseases.

Neuron-specific enolase (EC 4.2.1.11; NSE), a glycolytic enzyme produced by neuronal and neuroendocrine cells, is used as a tumor marker of neuroendocrine cancers, especially small-cell lung cancer. We have evaluated the behavior of NSE in nonmalignant liver diseases in 161 patients who underwent a thorough clinical and biochemical evaluation. Nine of the 161 patients (5.6%)--three of the 86 ci...

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Serum Neuron-Specific Enolase in Lead-Exposed Individuals.

The article by Ravibabu, et al, 1 provides important new data in the field of biomarkers to monitor exposures to lead within the workplace, as in the lead acid battery manufacturing. They found that the serum neuron-specific enolase (NSE) levels are not elevated in association with concentrations of blood lead levels among workers in the lead acid battery manufacturing plant. In our (unpublishe...

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ژورنال

عنوان ژورنال: Stroke

سال: 1999

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.30.8.1598